This Week In Sickle Cell News

Hello All!

Yesterday kicked off the REDAC 5th International Symposium on Sickle Cell Disease in Central Africa. The conference is being held this year in Kinshasa, DRC, and is a gathering of experts in the disease, who are actively engaged in research. This year's program includes the following topics:

• Clinical manifestations
• Complications and rare expressions
• Monitoring and management
• Genetics
• Markers of severity
• Susceptibility to infections
• Traditional and herbal medicine
• The role of HbF in clinical expression
• Malaria and sickle cell disease
• Marriage system and society
• Alpha thalassemia and beta S gene haplotypes

Updates if/as they become available.

This week's selection:

The Glomerulopathy of Sickle Cell Disease

Prevalence of Sickle Cell Trait in Four Tribal Communities of Visakhapatnam  District

Diabetic Ketoacidosis in Two Nigerian Adolescents with Homozygous Sickle Cell Anemia

Back Pain: The Sole of Presentation of Sickle Cell Disease

Anaesthetic Management of  a Patient with Sickle β+ Thalassemia with Cholelithiasis

Incidence of Hepatitis B Surface Antigen Among Sickle Cell Disease Patients Receiving Transfusion Therapy

Have an Excellent Weekend!

The ASN Team

This Week in Sicle Cell News

Hello All!

Sickle Cell Disease dramatically increases the odds of bacterial infections. The case is particularly so for African patients who reportedly face 13 - 36 times greater odds of infection with the presence of SCD.(Ramakrishnan et al, 2010)  Understanding this link between bacterial infections and SCD is crucial to the development of effective therapies for SCD patients. Researchers at St. Jude Children's Hospital in Memphis, TN, recently identified differences in the genetic code of pneumococcal bacteria that shed light on why  it poses such a risk to children with SCD and is resistant to  current vaccines.(Click for more). In another finding, researchers st the University of Texas Health Science Center at Houston have found that inhibiting the lipid mediator sphingosine kinase 1 (SphK1) in mice led to longer living and less sickle-prone red blood cells. Furthermore, they found that treating the blood of SCD patients with SphK1, led to fewer sickle cells. (Click for more)

These discoveries and those that follow indicate the strides being taken towards finding effective treatment for SCD patients worldwide!

More of this week's discoveries:

Surgical treatment of thoraco-lumbar fractures in sickle cell disease: A case report

Hydroxyurea therapy for priapism prevention and erectile function recovery in sickle cell disease: a case report and review of the literature

QT dispersion and QTc interval in patients with adult sickle cell disease: electrocardiographic (EKG) and echocardiographic evaluation

Epigenetic regulation of fetal globin gene expression in adult erythroid cells

Acute liver function decompensation in a patient with sickle cell disease managed with exchange transfusion and endoscopic retrograde cholangiography

Red blood cell alloimmunization mitigation strategies

 

Respiratory burst enzymes and oxidant-antioxidant status in nigerian children with sickle cell disease. 

 

The effect of deferasirox on the oxidative stress and inflammation in iron overloaded beta-thalassemic patients

 

Organ preservation in splenic abscess

 

 

Have a Wonderful Weekend!

 

 

The ASN Team.

This Week In Sickle Cell News

Hello All!

Before exploring this weeks selection of the latest in Sickle Cell research news, a quick reminder about the Fifth International Symposium on Sickle Cell Disease in Central Africa organized by the Global Sickle Cell Disease Network. It will be held from May 29, 2014 - May 31, 2014 in Kinshasa, DRC, under the theme  "Sickle Cell Disease in Central Africa: Clinics, Genetics and Environment."

This week's selection:

Induced pluripotent stem cells in hematology: current and future applications

Expression of the iron hormone hepcidin distinguishes different types of anemia in african children

Using an Electronic Health Record-Based Registry to Improve Pediatric Sickle Cell Care

Transcriptional and epigenetic basis for restoration of G6PD enzymatic activity in human G6PD-deficient cells

Patient-centered Approach to Designing Sickle Cell Transition Education

Have a wonderful weekend!

The ASN Team

This Week In Sickle Cell News

Hello All!

This weeks findings:

 Frequency of Sickle Cell Trait among Relatives of Sickle Cell Anemia Patients in Al-Gadaref State-Sudan.

First evidence of subclinical renal tubular injury during sickle-cell crisis.

Comment on “Influence of βS-globin haplotypes and hydroxyurea on tumor necrosis factor-alpha levels in sickle cell anemia.”  See see original paper here.

Hematopoietic stem cell transplantation in thalassemia major and sickle cell disease: indications and management recommendations from an international expert panel.

Bradykinin Stimulation of Nitric Oxide Production is not Sufficient for Gamma-Globin Induction.

Rare Form of Autosomal Dominant Thalassemia—Hemoglobin Hakkari.

The Association of Social-Environmental Factors with Cognitive Function in Children with Sickle Cell Disease. (Masters Thesis)

Haemoglobin-D A Rare Case Report.

Zinc Status and its Correlation with Basic Parameters in Transfusion Dependent Thalassemic Patients: A Pakistani Perspective.

Splenectomy for Hematological Disorders

Study of double heterozygous hemoglobinopathy cases by using cation exchange High Performance Liquid Chromatography in Nanded region of Maharashtra 


Happy Weekend!

The ASN Team

This Week In Sickle Cell News

Hello!


This week's selection:



Verbal autopsy as a tool for identifying children dying of sickle cell disease: a validation study conducted in Kilifi district, Kenya

How I treat renal complications in sickle cell disease

A Call for Policy Action in Sub-Saharan Africa to Rethink Diagnostics for Pregnancy Affected by Sickle Cell Disease: Differential Views of Medical Doctors, Parents and Adult Patients Predict Value Conflicts in Cameroon

Low-dose Ketamine for Children and Adolescents with Acute Sickle CellDisease Related Pain: A Single Center Experience

Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia

Haemoglobinopathies – HbE and HbS among the Gallong Tribe of West Siang District of Arunachal Pradesh, India.

Using an Electronic Health Record-Based Registry to Improve Pediatric Sickle Cell Care


Happy Weekend!